토토 커뮤니티 순위PHYSICS/ BK21 Colloquium[09
관련링크
본문
"
Toward an Unified Description for Thermodynamics,
Folding Kinetics, and Mutagenesis of Proteins”
* Speaker : Prof. Ik Soo Chang[Pusan National University]
* Place : 토토 커뮤니티 순위 Seminar Room (Science Bldg, 3-201)
* Date & Time : Oct,토토 커뮤니티 순위16Fri)토토 커뮤니티 순위4:00 ~ 5:00 pm
Abstract
A multiscale-heterogeneous protein energy function was developed for the biophysical study of the
thermodynamics, folding kinetics, and mutagenesis of proteins. After hybridizing an토토 커뮤니티 순위atomic토토 커뮤니티 순위force-
field into a coarse-grained energy function to account for the specificity of a토토 커뮤니티 순위sequence토토 커뮤니티 순위of토토 커뮤니티 순위amino
acids even with the high structural homology, we constructed an exact free energy landscape of a
given protein and characterized its thermodynamics and folding-unfolding kinetics via토토 커뮤니티 순위a토토 커뮤니티 순위Chevron
plot based on solving exactly a master equation, which would enable us to pursue토토 커뮤니티 순위a토토 커뮤니티 순위mutagenesis
application. Our approach was applied successfully for resolving a controversy토토 커뮤니티 순위about토토 커뮤니티 순위the토토 커뮤니티 순위folding
mechanism of fast folding proteins.
Recent experiments claiming that BBL protein follows a global downhill folding raised an important
controversy as to the folding mechanism of fast folding proteins. Under the global downhill folding
scenario not only proteins undergo a gradual folding, but also folding events along the continuous
folding pathway could be mapped out from the equilibrium denaturation experiment. Based on the
exact calculation using a free energy landscape, relaxation eigenmodes from토토 커뮤니티 순위a토토 커뮤니티 순위master토토 커뮤니티 순위equation,
and Monte Carlo simulation of an토토 커뮤니티 순위extended토토 커뮤니티 순위Munoz-Eaton토토 커뮤니티 순위model토토 커뮤니티 순위that토토 커뮤니티 순위incorporates토토 커뮤니티 순위multiscale-
heterogeneous pairwise-interactions between amino acids, here we show that the very nature of a
two-state cooperative transition such as a bimodal distribution from an exact free energy landscape
and biphasic relaxation kinetics do manifest in the thermodynamics토토 커뮤니티 순위and토토 커뮤니티 순위folding-unfolding토토 커뮤니티 순위kinetics
of BBL and peripheral subunit-binding domain (PSBD) homologue. Our results provide an unequivocal
resolution to the fundamental controversy related to토토 커뮤니티 순위the토토 커뮤니티 순위global토토 커뮤니티 순위downhill토토 커뮤니티 순위folding토토 커뮤니티 순위scheme,토토 커뮤니티 순위whose
applicability to other proteins should be critically re-examined.
Contact Person : Prof. Ki Bong Lee (054-279-2068, kibong@postech.ac.kr)
"
Toward an Unified Description for Thermodynamics,
Folding Kinetics, and Mutagenesis of Proteins”
* Speaker : Prof. Ik Soo Chang[Pusan National University]
* Place : 토토 커뮤니티 순위 Seminar Room (Science Bldg, 3-201)
* Date & Time : Oct,토토 커뮤니티 순위16Fri)토토 커뮤니티 순위4:00 ~ 5:00 pm
Abstract
A multiscale-heterogeneous protein energy function was developed for the biophysical study of the
thermodynamics, folding kinetics, and mutagenesis of proteins. After hybridizing an토토 커뮤니티 순위atomic토토 커뮤니티 순위force-
field into a coarse-grained energy function to account for the specificity of a토토 커뮤니티 순위sequence토토 커뮤니티 순위of토토 커뮤니티 순위amino
acids even with the high structural homology, we constructed an exact free energy landscape of a
given protein and characterized its thermodynamics and folding-unfolding kinetics via토토 커뮤니티 순위a토토 커뮤니티 순위Chevron
plot based on solving exactly a master equation, which would enable us to pursue토토 커뮤니티 순위a토토 커뮤니티 순위mutagenesis
application. Our approach was applied successfully for resolving a controversy토토 커뮤니티 순위about토토 커뮤니티 순위the토토 커뮤니티 순위folding
mechanism of fast folding proteins.
Recent experiments claiming that BBL protein follows a global downhill folding raised an important
controversy as to the folding mechanism of fast folding proteins. Under the global downhill folding
scenario not only proteins undergo a gradual folding, but also folding events along the continuous
folding pathway could be mapped out from the equilibrium denaturation experiment. Based on the
exact calculation using a free energy landscape, relaxation eigenmodes from토토 커뮤니티 순위a토토 커뮤니티 순위master토토 커뮤니티 순위equation,
and Monte Carlo simulation of an토토 커뮤니티 순위extended토토 커뮤니티 순위Munoz-Eaton토토 커뮤니티 순위model토토 커뮤니티 순위that토토 커뮤니티 순위incorporates토토 커뮤니티 순위multiscale-
heterogeneous pairwise-interactions between amino acids, here we show that the very nature of a
two-state cooperative transition such as a bimodal distribution from an exact free energy landscape
and biphasic relaxation kinetics do manifest in the thermodynamics토토 커뮤니티 순위and토토 커뮤니티 순위folding-unfolding토토 커뮤니티 순위kinetics
of BBL and peripheral subunit-binding domain (PSBD) homologue. Our results provide an unequivocal
resolution to the fundamental controversy related to토토 커뮤니티 순위the토토 커뮤니티 순위global토토 커뮤니티 순위downhill토토 커뮤니티 순위folding토토 커뮤니티 순위scheme,토토 커뮤니티 순위whose
applicability to other proteins should be critically re-examined.
Contact Person : Prof. Ki Bong Lee (054-279-2068, kibong@postech.ac.kr)
"
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